Metaplasticity and the Unified Calcium Model lead to input selectivity in spiking neurons
نویسندگان
چکیده
Intracellular calcium concentration has been proposed as the key associative signal for the Hebbian synaptic plasticity. The Unified Calcium Model has been able to account for various plasticityinduction protocols, such as rate-based and spike time-dependent plasticity. Here, we investigate the properties of this model in a multi-synapse neuron receiving inputs with different spatiotemporal spiketrain statistics. In addition, we present a physiological form of metaplasticity, an activity-driven robustnessinducing regulation mechanism. A neuron thus implemented is stable and spontaneously develop selectivity to a subset of the stimulating inputs.
منابع مشابه
Selectivity and Metaplasticity in a Unified Calcium-Dependent Model
A unified, biophysically motivated Calcium-Dependent Learning model has been shown to account for various rate-based and spike time-dependent paradigms for inducing synaptic plasticity. Here, we investigate the properties of this model for a multi-synapse neuron that receives inputs with different spike-train statistics. In addition, we present a physiological form of metaplasticity, an activit...
متن کاملEnhanced polychronization in a spiking network with metaplasticity
Computational models of metaplasticity have usually focused on the modeling of single synapses (Shouval et al., 2002). In this paper we study the effect of metaplasticity on network behavior. Our guiding assumption is that the primary purpose of metaplasticity is to regulate synaptic plasticity, by increasing it when input is low and decreasing it when input is high. For our experiments we adop...
متن کاملSilencing-induced metaplasticity in hippocampal cultured neurons.
Silencing-induced homeostatic plasticity is usually expressed as a change in the amplitude or the frequency of miniature postsynaptic currents. Here we report that, prolonged (approximately 24 h) silencing of mature (20-22 days in vitro) cultured hippocampal neurons using the voltage-gated sodium channel blocker tetrodotoxin (TTX) produced no effects on the amplitude or frequency of the miniatu...
متن کاملImproving the Izhikevich Model Based on Rat Basolateral Amygdala and Hippocampus Neurons, and Recognizing Their Possible Firing Patterns
Introduction: Identifying the potential firing patterns following different brain regions under normal and abnormal conditions increases our understanding of events at the level of neural interactions in the brain. Furthermore, it is important to be capable of modeling the potential neural activities to build precise artificial neural networks. The Izhikevich model is one of the simplest biolog...
متن کاملMetaplasticity Governs Natural Experience-Driven Plasticity of Nascent Embryonic Brain Circuits
During embryogenesis, brain neurons receiving the same sensory input may undergo potentiation or depression. While the origin of variable plasticity in vivo is unknown, it plays a key role in shaping dynamic neural circuit refinement. Here, we investigate effects of natural visual stimuli on neuronal firing within the intact, awake, developing brain using calcium imaging of 100 s of central neu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2003